And now a little about how suppositories work:
The superior rectal veins drain to the portal circulation via the inferior mesenteric vein. The middle and inferior rectal veins, however, drain to the systemic circulation via the internal iliac and internal pudendal veins, respectively. Thus, two-thirds of the venous drainage of the rectal region goes directly into the systemic circulation, thereby increasing the bioavailability of drugs that are otherwise highly cleared by the liver after oral administration.
0 comments:
Post a Comment